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KMID : 0381219780100030031
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Journal of RIMSK
1978 Volume.10 No. 3 p.31 ~ p.38
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Studies on the Changes of the Number of the Immunocompetent cells in the Regional Lymph Nodes of the patients with Gastric Carinoma
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Abstract
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What parameters dictate whether a given tumor will metastasize?
The answer to this question is not fully understood at this time, but certainly one factor, host immune response, plays an important role in this phenomenon. Host immune response could be modulated by two factors, immunocompetence of the host and tumor antigenicity.
The authors tested the first hypothesis by studying two gastric lesions, i. e. chronic peptic ulcer and adenocarcinoma, because Cerottini and Brunner reported that in vivo immunization in the mouse with allogenic or syngeneic malignant cells results in the development of thymus derived (T) cytotoxic effector cells. Lamon, et al. and Plata, et al. reported that virus-induced murine tumors stimulate both thymus- dependent and thymus independent effector cells during different phases of tumor development. And MacLennan reported that injection of xenogeneic cells into the rat has been shown to raise a population of thymusindependent effector cells.
In order to confirm the immune reaction type in the patients of gastric carcinoma, the authors selected 59 regional lymph nodes from 12 gastric cancer patients and 45 regional lymph nodes from 16 chronic peptic ulcer patients. Among the 59 lymph nodes from cancer patients, 25 nodes represented metastatic growths and remaining nodes repesented no definitive evidence of metastasis.
The nodes were formaline-fixed and paraffin-embedded and then stained with methyl greenpyronine staining and fluorescent antigen-antibody staining methods, which were induced from rabbit immunized with crude human gamma globulin.
The following results were ensued:
1. The number of pyroninophilic cells in the paracortical region of the regional lymph
nodes from gastric cancer (16.5?9.77/High power field) are greater than that of chronic peptic ulcer of the stomach (5.6±3.07/High power field).
2. The number of pyroninophilic cells in the germinal center of the regional lymphnodes from gastric cancer (9. 0±8. 52/High power field) are greater than that of chronic peptic ulcer of the stomach (3.4±2.24/High power field).
3. The number of Fluorescent positive cells for human gamma globulin in the paracortical region of the regional lymph nodes from gastric cancer (13.9±15.42/High power field) are greater than that of chronic peptic ulcer of the stomach (5.8±4.72/High power field).
4. The number of Fluorescent positive cells for human gamma globulin in the ´follicle of the regional lymphnodes from gastric cancer (2.8±1.94/ High power field) are greater than that of chronic peptic ulcer of the stomach (1.4±1.72/High power field).
5. The number of pyroninophilia cells in the paracortical region of the regional lymphnodes from gastric cancer with lymphnode involvement (21.7±11. 13/High power field) are greater than that of gasrtic cancer without lymphnode involvement(12.7±6.33/High power field).
6. The number of pyroninophilic cells in the germinal center of the regional lymphnodes from gastric cancer with lymphnode involvement (13.0±11.47/High power field) are greater than that of gastric cancer without lymphnode involvement (6.2±3. 10/High power field).
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